Peptides for Weight Loss: Therapy & Guide

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Using peptides for weight loss has become increasingly popular due to its positive results. Before, peptide therapy was mostly known for promoting optimal hormone levels and mitigating aging.

Peptides were popularized in recent years by biohacking gurus such as Ben Greenfield and Dave Asprey.

They have become famous in the fitness community as well as in biohacker circles and transhumanist groups.

And no wonder, since peptides have powerful anti-aging powers and great ability to eliminate body fat, all without significant side effects.

That is why more and more people are adding peptides to their supplementation regimen.

What are peptides?

Peptides are defined as the compound of two or more amino acids where the carboxyl group is linked to the amino group.

With the removal of a water molecule, a peptide bond is formed.

To put it another way, peptides are proteins but on a smaller scale. When peptides go beyond 50 amino acid bonds, they are considered proteins.

What is the function of peptides?

In the human body, peptides are found in every cell and perform multiple essential functions. Maintaining appropriate levels of peptide concentration and activity is necessary to achieve balance and maintain health.

As the body ages and experiences different stress levels, the endogenous production of amino acids and peptides decrease. This is one of the reasons why the body begins to weaken with age.

Also, why we gain fat instead of muscle and why our skin starts to lose its elasticity.

This is where synthetic peptides come into play: they are designed to stimulate endogenous production of growth hormone (HGH) and IGF-1 (Insulin Growth Factor 1) or “insulin-like growth factor.”

IGF-1 is a key hormone involved in muscle growth.

U.S. National library of medicine

For starters, we need to understand how our bodies work. At the base of our brain is a small gland called the pituitary gland.

The pituitary gland is the control unit for other hormone glands, for example, the adrenals and thyroid, which are vital for a large part of body control and overall well-being.

To maintain a sustainable balance in the body, the pituitary gland sends signals to the circulatory system and other organs and glands.

In this way, it regulates or produces its own hormones as needed.

How do peptides work?

Peptides have a direct impact on the way the body reacts to diet and exercise. These peptides contribute to your body’s natural production of human growth hormone (HGH) and IGF-1.

Human Growth Hormone is produced naturally in the body and affects almost every part of it, from muscles to bones, nervous system, skin, and even hair.

It is known as the “youth hormone.” When we reach our 30s, our natural production of HGH begins to decline.

HGH is produced in the pituitary gland and circulates through the blood to the liver, stimulating the production of insulin-like growth factor (IGF-1).

IGF-1 plays a crucial role in muscle development and the body’s natural HGH production mechanism.

When HGH levels are low, the hypothalamus releases HGH stimulators called growth hormone-releasing hormones (GHRH). If levels are high, it reduces production.

By not absorbing and producing enough amino acids, the body cannot generate enough peptides. And when these peptides can’t be produced, your HGH production is reduced.

This is why synthetic peptides are becoming a natural attraction for many sportspeople, athletes, or people who want to lose weight.

Peptides for weight loss and other benefits of peptide therapy

The documented benefits of HGH and IGF-1 secretagogue peptides are as follows:


Once the peptide is applied (via subcutaneous injection with an insulin syringe), a selective pulse is sent to the pituitary gland.

This releases growth hormone naturally and increases the pituitary gland’s own levels of growth hormone production.

All the studies conducted show that the safety profile of peptides is very high. In most cases, these peptides are synthetic versions of endogenous peptides that are produced in the body.

The peptide market is not regulated by any health organization.

Therefore, it is imperative to find a supplier that demonstrates their products’ authenticity and purity. This ensures that the peptides are not adulterated, contaminated, or counterfeit.

How is peptide therapy applied?

peptides for weight loss

Peptides have no oral bioavailability. Therefore, they are administered by subcutaneous injection with an insulin syringe.

Peptide shots vs human growth hormones:

One might ask why to inject peptides that stimulate human growth hormone production instead of HGH.

The short answer is that peptides generate far fewer side effects than exogenous HGH. They are also much cheaper.

Unlike peptides, the application of exogenous Human Growth Hormone can cause the following side effects:

  • Carpal tunnel syndrome
  • Joint, muscle, or nerve pain
  • Arms and legs swelling due to fluid retention (edema)
  • High cholesterol levels
  • Numbness and tingling of the skin
  • Increased risk of heart disease and diabetes
  • Possible growth of tumors
  • Growth of facial features, hands, and feet (acromegaly)
  • Mood changes, dependence
  • Organ growth
  • Low blood sugar and insulin problems
  • Liver damage
  • Fatigue
  • Gynecomastia in men

The use of peptides does not cause these side effects.

Peptides for weight loss and muscle mass

Here is a list of the most potent peptides to lose weight and gain muscle mass. However, there are other types of peptides (cosmetic, functional, injury rehabilitation, cognitive enhancers…) that we may study in future publications.

Ipamorelin is one of the most commonly used in peptide therapy.

Unlike other growth hormone secretagogues, this pentapeptide does not release cortisol, acetylcholine, prolactin, or aldosterone.

For this reason, Ipamorelin is considered to be the first selective HGH secretagogue peptide.

Ipamorelin is generally used in combination with a peptide of the GHRH (Growth Hormone Releasing Hormone) class, such as CJC-1295 non-DAC (also known as Mod GRF 1-29).

This combination is recommended for people who want to have all the advantages of a peptide therapy without experiencing side effects or increased appetite.

The perfect complement to Ipamorelin. CJC-1295 non-DAC stimulates growth hormone secretion and maintains a steady increase in HGH and IGF-1 without prolactin increase.

This mechanism leads to fat loss and increased protein synthesis, which promotes muscle growth.

It is suggested to use CJC-1295 in combination with Ipamorelin because of the high synergy these two peptides have: Ipamorelin drives an HGH release flux, while CJC-1295 amplifies it.

The combination allows for a maximized release of HGH and IGF-1.

Growth hormone is a polypeptide of 191 amino acids. The last 16 amino acids (176-191) of the growth hormone polypeptide have been reproduced as a specific peptide and correspond to the HGH Fragment 176-191 peptide (also known as AOD-9604).

HGH Fragment 176-191 possesses a powerful ability to regulate metabolism and help with fat tissue loss without causing side effects such as hunger or insulin problems.

It is the most potent peptide to promote the elimination of body fat.

HGH Fragment 176-191 can be combined with Ipamorelin and CJC-1295 No DAC cycle to achieve dramatic body fat elimination results.

These 2 peptides have similar effects to ipamorelin but are slightly more potent.

However, unlike Ipamorelin, they are not selective and cause an increase in cortisol and prolactin levels. Therefore, peptide users prefer to use Ipamorelin.

Also, GHRP-2 and GHRP-6 tend to increase appetite very intensely, and obviously, this side effect may not be worth it if your main goal is to reduce body weight.

How to achieve the best possible results with a peptide cycle?

peptide cycles

The regimen recognized as one of the most effective for losing weight and gaining body mass is the combination of Ipamorelin + CJC-1295 No DAC.

The standard recommended cycle when using peptides for weight loss is 50 days.

To achieve even more dramatic results in body fat elimination, you can combine this Ipamorelin and CJC-1295 No DAC cycle with a Fragment HGH 176-191 cycle.

Which other products can the peptides be combined with to optimize their effects?

The mechanism of action of peptides is highly complementary to that of SARMs. Therefore peptides offer even better results when combined with a SARM such as Ostarine or LGD-4033.

The following peptides can also be used as therapy. Each has unique growth hormone-related effects but are not as widely used as the above peptides for several reasons (high cost, undesirable side effects, and limited efficacy):

  • Hexarelin
  • Tesamorelin
  • Sermorelin
  • IGF1-LR3
  • Follistatin
  • Mechano Growth Factor (MGF)
  • PEG-MGF

Peptides for weight loss: Conclusion

Peptide therapy can be an excellent treatment option for women and men facing weight-related problems, low energy levels, aging, or other health issues that affect their overall quality of life.

This therapy allows you to eliminate body fat, increase muscle mass, increase skin elasticity, increase energy levels and improve sleep quality safely and without noticeable side effects.

Hormones are chemical messengers that regulate metabolic processes in our body.

According to the World Health Organization (WHO), our health depends on the proper functioning of the endocrine system, among other factors, since it regulates the release of essential hormones for issues such as metabolism, growth and development, sleep, and mood.

Besides, hormones influence weight because hormone excesses or deficiencies can lead to obesity, but obesity can also lead to changes in hormone secretion.

It is important to clarify that obesity is related to a hormonal issue, but it is a chronic disease that requires long-term medical treatment.

Since its nature is complex and multifactorial, genetic, physiological, environmental, and psychological factors are associated with serious health consequences.

Adipose tissue is an endocrine organ that secretes numerous hormones such as leptin and insulin.

These hormones, along with cortisol, growth hormone, and others, influence increased appetite, metabolism (the rate at which the body burns calories for energy), and body fat distribution.

People who are overweight or obese have hormone levels that promote abnormal metabolism and body fat accumulation.

“Cortisol is one of the most influential hormones on weight, as it controls lipid, protein, and glycemic metabolism. It generates a phenotype characterized by visceral obesity, diabetes or insulin resistance, and arterial hypertension when it is altered. This hormone also indirectly influences appetite by regulating other chemicals that are released during stress, such as CRH (corticotropin-releasing hormone) and leptin,” says Victor Nolasco, M.D., Medical Manager of Novo Nordisk CLAT.

According to Nolasco, Leptin acts by inhibiting appetite, activates energy expenditure (fat loss), and affects numerous metabolic processes.

On the other hand, insulin regulates the amount of glucose in the blood. It is key to weight control since it’s responsible for more or less fat or generating more muscle mass when the body synthesizes proteins.

The different types of hormones play vital roles in controlling certain biological processes in the body and condition behavior and even mood, which influences the way we eat and vice versa.

A hormonal imbalance can lead to depression or make you feel and see “reality” differently. One of the main hormones that affect behavior and mood is cortisol, which is responsible for activating stress and anxiety.

 “When we are happy, our appetite tends to be somewhat normal, but if we are sad or under stress, it tends to decrease; however, sometimes the opposite effect can also happen, and we binge,” expressed Nolasco, which is why he emphasizes the need to work hand in hand with a medical professional to cope with obesity as a disease that requires comprehensive care. 

The specialist also offers some practical recommendations that, combined with medical attention, can help your endocrine system maintain a healthy balance:

  • Get enough sleep: it is recommended that you get between 7-8 hours of sleep daily, as failure to do so could contribute to weight gain
  • Stay active: at least three times a week. Going for a walk, jog or run helps to clear your mind and release stress
  • Self-care: it is a time of little social activity, so it can translate into an opportunity to maintain a healthy diet and take care of your personal needs
  • Enhance social relationships: lean on friends and family, call them and talk to them. Share experiences and empathize with each other

Whether you want to use peptides for weight loss or other reasons, always consult with your doctor first. Don’t forget to share your experiences with us! Stay safe and healthy.

peptides for weight loss

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Joel Zazueta

Hey! Joel here; A graduate of Herbalism & Naturopathy Medicine School. My team and I are passionate about finding ways to improve our lives on a daily basis and truly believe in natural alternatives of doing so before seeking traditional medications. However, always consult with your Doctor/Physician first before taking any actions in regards to your health. Stay Safe and Healthy!

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